0Shares0000Mohamed Salah was on target in Liverpool’s win over Southampton © AFP / Paul ELLISLIVERPOOL, United Kingdom, Sep 22 – Jurgen Klopp admitted Liverpool’s flying start has surprised him as they won their sixth successive Premier League game to return to the top of the table.The comfortable 3-0 victory over Southampton at Anfield was wrapped up by half-time on Saturday courtesy of an own goal from Wesley Hoedt, Joel Matip’s header and Mohamed Salah’s simple finish. The victory marked Liverpool’s best start to a season since they won eight league games in a row in 1990-91.Klopp’s red-hot men have now won seven successive matches in all competitions this term.Southampton manager Mark Hughes, now without a league win in 12 visits to Anfield with six different teams, admitted the second half was simply “damage limitation” for the Saints.And Klopp was happy to welcome another unexpected milestone on his team’s journey.“I lost seven games in a row once, that felt different! But then we won game number eight 5-0, very cool,” he said.“It’s a surprise, but all the performances we showed so far were good enough to win the games.“Different challenges, different styles of opponent, the boys were there, really in the situation and in the game.”Klopp was also able to offer good news on the only possible downsides on the day for Liverpool, the half time removal of Xherdan Shaqiri and the second half substitution of Virgil van Dijk, who left the pitch clutching his ribs.Klopp revealed Shaqiri’s early substitution in his first Liverpool start was purely tactical despite his involvement in the build up to the first goal – his shot hit Shane Long before going in off Hoedt – and his superb 25 yard free-kick against the bar which led to Salah’s tap-in for the third.“I said to Shaq at half time that I’d never taken a player off at half time after such an influential half,” Klopp said.“He was not injured, but I wanted to control the game, go back to our normal formation, and that helped us.”The Swiss international understood the decision, according to his manager.“He’s a fantastic boy so there was no problem. I explained it to him, usually I don’t explain substitutions but I thought today it made a bit of sense,” Klopp added.“It’s just good to have him. You saw the free kick, it was outstanding. What a ball!”– Cutting edge –Van Dijk, said Klopp, aggravated bruised ribs which he carried into the PSG game in midweek.“He had already before the PSG game kind of a bruised rib, which is very uncomfortable, and today he got another hit there,” he said.“It’s not cool, but should not be too serious.“He said he couldn’t shout any more, so that’s obviously 60 per cent less of his level!”Klopp’s 600th competitive game as a manager saw Liverpool extend an impressive home league record, unbeaten now in 18 games and 17 months at Anfield.No opposing player has even scored here in the league since February, with Liverpool scoring 23 in the same period.While the Saints enjoyed some promising moments they could not find the cutting edge to worry their opponents.The second half was rather a non-event with Salah’s disallowed finish after James Milner’s shot was cleared off the line the closest Liverpool came to adding gloss to the scoreline.Hughes thought 3-0 was harsh on his side but added: “We faced a quality side today. We’re not the first and won’t be the last not to cope with their attacking threat.“We didn’t really give ourselves a chance in the opening period, we were too easy to create chances against though we were unfortunate with the opening goal.”The victory ended a positive week for Liverpool with a third win after a statement victory against top four rivals Spurs at Wembley last weekend and the breathless, late victory against Paris St Germain in the Champions League.0Shares0000(Visited 2 times, 1 visits today)
Fenerbahce star Nani in action 1 Manchester United haven’t had the greatest weekend.Manchester City won again and signed won of the best midfielders in Europe, and they failed to capitalise on Chelsea’s defeat as they too lost.And just hours after the 2-1 defeat to Swansea, where the Red Devils looked toothless, they were given a reminder of what they’ve lost this summer as Nani grabbed a double for Fenerbahce.His first was a superb header from a Robin van Persie cross and his second was free-kick in added time to hand them a 2-1 win over Antalyaspor.You can see the goals below…
Liverpool Ladies celebrate their title success A Liverpool manager will be departing at the end of the season – but it is Matt Beard, not Brendan Rodgers, who will be leaving his post!Beard has been a huge sucess in his role as boss of the Merseyside club’s Ladies team, leading them to two successive Super League titles.He has now been tempted to America by Boston Breakers, who play in the popular National Women’s Soccer League.Beard will continue in his role as Liverpool Ladies manager until the end of this season before making the move Stateside.“The decision to leave Liverpool Ladies is one that I have thought a great deal about and was a really tough decision to make,” said Beard.“However, having enjoyed three fantastic years here and having spent 11 years working in the top flight of women’s football in England, I feel like I need a new challenge and I feel I have taken the club as far as I can.“I would like to thank all of the players and staff that I have worked with during my tenure as Liverpool Ladies manager. I have had some fantastic times with the club and will take some memories that will last forever.“I would also like to thank the Liverpool Ladies supporters who, in my opinion, are the best supporters in the Women’s Super League.“The backing that we have received both home and away has been nothing short of fantastic and I would like to express my gratitude to the fans for the backing they have given to the team.“I am extremely excited at the prospect of challenging myself abroad in a league as competitive as the National Women’s Soccer League with Boston Breakers.“The move is a decision I have not taken lightly and will be a big move for both myself and my family, but is a challenge that I cannot wait to get started.”Ian Ayre, Liverpool’s chief executive officer, added: “It has been an incredible story for our Liverpool Ladies team, winning back-to-back league titles and qualifying for the Champions League for the first time.“Matt has been at the very heart of that success and we thank him for his contribution and wish him well in his new challenge. The search for a new manager will begin immediately to build on the progress made to date.” 1
A young Letterkenny man has been told to “start saving” by a judge after he was caught with €825 worth of cannabis.Christopher Rogers was caught with the drug at 22 Ashfield, Letterkenny on February 11th, 2011.However Rogers claimed he was merely supplying the drug to friends and was not making any profit on it. Gardai told Letterkenny District Court that Rogers had access to people with the drugs which his friends did not have.The defendant’s solicitor told the court that his client had ben an ordinary young man until he developed a muscular complaint which prevented his from taking part in sport.He the turned to using cannabis and mixing with the wrong crowd.Gardai told the court that they believed Rogers would not come before them again and that he had learned a hard lessonThey added that they believed it was a ‘one time occurrence.’However Judge Paul Kelly said he would be first interested in hearing a probation report on Mr RogersThe court heard that Rogers was working in the UK but that he would return for trial on October 15th.JUDGE TELLS MAN TO ‘START SAVING’ AFTER CANNABIS FIND was last modified: July 17th, 2012 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:cannabisChristopher Rogersletterkenny
St Eunan’s GAA News:This year’s Football Cúl Camp will take place in O’Donnell Park starting next Monday July 27th and running to July 31st.The Hurling / Camogie Camp is from Mon. August 10th – Fri. Aug. 14th We would ask people to kindly book in advance to ensure we have the correct coaches to children ratios.Further details on the Club Facebook page and online booking available on the links below:https://secure.kelloggsculcamps.gaa.ie/booking/…https://secure.kelloggsculcamps.gaa.ie/booking/…Members wishing to order tickets through the club can to send their order by TEXT only to Charlie on 087 2668633 or Mickey on 087 9499614 before 6pm this Thursday evening 23/7/2015.The Senior Hurlers take on Burt this Saturday evening at home in their second Championship match, throw in 7.30pm. The Senior Footballers defeated Dungloe in the league by 1-11 to 0-06, Lee McMonagle getting the goal with a brilliant effort. The Reserves won 2-08 to 1-03 with Donnacha Gallagher and Sammy Bogan getting the goals. Both teams are fixed to host Malin in the Park this Sunday at 1.30pm and 3pm.The Junior Footballers defeated Glenfin by 2-11 to 0-05 to remain two points clear at the top of Division 5. They travel to Downings this Saturday evening for their second group match in the Championship, throw in 6pm.The Minor Boys Football team were defeated 1-09 to 1-03 in their re-arranged Northern Board League final on Monday.The U-16 hurlers defeated the Letterkenny Gaels last Thursday and play Strabane in the league this Thursday in O’Donnell Park at 7pm. U-16 hurling training continues on Tuesdays at 5pm with new hurlers always welcome.The U-14 Boys football team won their league semi final with an emphatic 5-15 to 2-03 win over Naomh Conaill and will take on Urris in the final this Friday evening at 7.30pm in Convoy. Hard luck to our U-14 girls who fell short in the County Final last weekend, losing to Termon by 2-11 to 0-10.The U-12 hurlers defeated Letterkenny Gaels last week and are away to Four Masters this week.Well done to our U-14 and U-16 hurlers on the Donegal teams who were undefeated in their respective tournaments on Saturday with Ryan Hilferty captaining the U-16 team to victory in the Peter O’Keefe Tournament.Congratulations to Paddy Flood and our players on the Donegal U-21 Hurling team who defeated Sligo by one point in the All Ireland (c) semi final at the weekend. Best of luck to all as they face Tyrone in the Final this Sunday at 6.30pm in Celtic Park, Derry. The Hurling Academy continues every Friday evening at 6.30pm, while the Century Cinemas Football Academy is on Sundays at 11am. New members are always welcome to both academies. For more information, please contact Ciaran Maguire, 087 4133372, Eugene Duffy, 086 8430240 or Eunan O’Donnell 087 6775637.The Clubhouse at O’Donnell Park is now available to book for parties, functions, etc. Contact Niall on 086-3062893 for further information/bookings.Please note any amendments to fixtures etc. will be noted on the Club Facebook Page as soon as confirmation is received.Congratulations to Adam Ashforth who won our €500 ‘Saint of St. Ardrew’s’ Golf prediction competition. Adam picked Louis Oosthuizen, Marc Leishman and Branden Grace and finished two shots ahead of Tyrone man Mark Harte. Well done to Adam and thanks to the 250 plus people who entered. Thanks also to the organising Committee and sellers and particularly Ciaran Haran who done a huge amount of work behind the scenes.This weeks winning numbers are 4,6,15,23There were 3 x match 3 winners each getting €35James Doherty, Churchhill (Direct Debit)Tony Diver, c/o Central BarRosemaire Doherty, The GrangeAbove sold by AdrianNext week’s jackpot is €1450.Sincere sympathy is extended to the Johnston family, Crieve on their recent bereavementGAA NEWS: ST EUNAN’S SENIOR HURLERS FACE BURT IN CHAMPIONSHIP CLASH was last modified: July 21st, 2015 by Mark ForkerShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)Tags:GAANoticesSportSt Eunans
Chelsea will be looking to continue their splendid start to the season when they take on Bournemouth at Stamford Bridge on Saturday at 15:00.The Blues have won their opening three games this season – their last coming in a dramatic 2-1 victory at Newcastle. The Chelsea boss has no injury concerns ahead of the game so we believe he will stick with the same line-up for their win last weekend.At his press conference, Sarri also said he will give Ruben Loftus-Cheek a chance to prove himself over the coming weeks as the fixtures intensify later in September. Which teams do the best on Boxing Day in the Premier League era? silverware gameday cracker Chelsea have looked the real deal so far this season possible standings REVEALED Every current Premier League club’s best kit from the past decade 2 Where Ancelotti ranks with every Premier League boss for trophies won REVEALED shining smart causal tense Latest Chelsea FC News How the Premier League table could change after the Boxing Day fixtures England’s most successful clubs of the past decade, according to trophies won 2 However, the Blues will be wary of their opponents who have picked up seven points out of a possible nine this season, including a good fightback draw against Everton last weekend.But the home side will still be favourites to win this clash. Here is talkSPORT predicted Chelsea line-up: Boxing Day fixtures: All nine Premier League games live on talkSPORT Premier League Team of the Season so far, including Liverpool and Leicester stars Green reveals how he confronted Sarri after Chelsea’s 6-0 defeat at Man City
The Assam government on Saturday suspended two officers for a “security lapse” during Chief Justice of India Ranjan Gogoi’s visit to the Kamakhya temple here on October 17.The two officers are Deputy Commissioner of Police (West) Bhanwar Lal Meena and Additional Deputy Commissioner, Kamrup (Metro), Prasanta Pratim Kathkotiya.An order signed by Home Secretary Deepak Mazumdar said lapse in security arrangements had caused inconvenience to Chief Justice Gogoi. The decision to suspend Mr. Meena was taken after Governor Jagdish Mukhi took a serious note of the lapse.The order pointed out that the itinerary of the CJI had been intimated to the Assam government department concerned on October 11.The government issued another order suspending Mr. Kathkotiya. “Action was taken against him for lack of coordination during the CJI’s visit,” Deputy Commissioner, Kamrup (Metro), Virendra Mittal said.A senior police officer said the “security lapse” had to do more with a “situation” arising out of “a rush of VIP movements” at Kamakhya on that day. The CJI’s visit had almost coincided with that of Bharatiya Janata Party president Amit Shah.According to news portal insidene.com and a couple of vernacular dailies, Chief Justice Gogoi was made to wait for at least 30 minutes as Mr. Shah had visited the temple at the same time along with Assam Chief Minister Sarbananda Sonowal, Finance Minister Himanta Biswa Sarma and other senior BJP leaders.“The temple that day was open for about 180 minutes because of Durga Puja. Everyone, including devotees, had to be accommodated during that period and the situation got complicated because of lack of coordination among the officials,” a temple priest was quoted as saying. “The suspension was a face-saving measure by the BJP government, which gave more importance to the security of Amit Shah than the Chief Justice of India,” Debabrata Saikia, CLP leader said on Sunday.
The U.S. Department of Energy (DOE) announced today two major efforts to push supercomputing power well beyond where it is today. DOE will spend $325 million on two extreme-scale computers to be built at national labs in Oak Ridge, Tennessee, and Livermore, California. The agency will spend another $100 million on FastForward 2, a program designed to improve software and applications that will run on the new machines. Though the specifications for the new machines are still in flux, they’re expected to run at top speeds of between 100 and 300 petaflops. (Each petaflop is equal to 1015 floating-point operations per second.) That’s considered a key milestone toward the goal of creating the first exascale (1018 flops) supercomputer, the next major landmark in high-performance computing.“It’s great,” says Jack Dongarra, a supercomputing expert at the University of Tennessee, Knoxville. “[These machines] are one step away from exascale. This is the jumping point to get there,” Dongarra says. It also suggests that if the current pace of improvement in high-performance computing continues, the first exascale machine could come online somewhere around 2022 to 2023, Dongarra says. The Oak Ridge supercomputer, called Summit, will be open to the scientific community and is expected to run at up to 300 petaflops. Sierra, the Livermore machine, is expected to top out somewhere around 200 petaflops and will be used by the National Nuclear Security Administration to test the safety and security of U.S. nuclear weapons. Both the Summit and Sierra machines are expected to be delivered in 2017 and become operational in 2018.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)The speed of the both machines is expected to easily outpace the United States’ current speed champ, Titan at Oak Ridge, which tops out at 27 petaflops. They will also be faster than the current world record–holder, Tianhe-2, which reaches top speeds of almost 35 petaflops at China’s National Supercomputer Center in Guangzhou. Although, Dongarra says that engineers are already working to boost the speed of Tianhe-2 to about 100 petaflops, and may do even more later.The design of the new machines is expected to continue a recent trend in revamping the way top supercomputers are built. Engineers previously boosted supercomputing power by adding additional central processing units (CPUs) that serve as the brains of the machine. But these chips are power-hungry. So simply adding more and more isn’t a viable way to get to exascale. Instead, these new machines will increase the use of graphics processing units (GPUs) that accelerate certain calculations, as well as add new high-speed interconnections between GPUs and CPUs. As a result, even though Summit is expected to have five to 10 times higher performance than Titan, it will use only 10% more power. The components for the new machine will be built by IBM, NVIDIA, and Mellanox.The new computers are expected to enable discoveries in fields ranging from materials science and biofuels development to combustion research and nuclear weapons engineering. “High-performance computing is an essential component of the science and technology portfolio required to maintain U.S. competitiveness and ensure our economic and national security,” said DOE Secretary Ernest Moniz in a statement.
Even the researchers whose trial of a potential drug for Ebola made headlines last week worked hard to downplay the glimmer of efficacy it showed. “It is a weak signal in a nonrandomized trial,” Yves Levy, director of the French Institute of Health and Medical Research (INSERM) in Paris told Science about the data, which INSERM has not released. Weak or not, the report in The New York Times that favipiravir, a Japanese flu drug, had halved mortality in one group of Ebola patients in Guinea was one more piece of good news that is complicating prospects for trials of other Ebola drugs.The Guinean government has already announced it wants to make favipiravir available to more people, and if the results hold up to greater scrutiny, they could force a change in the design of other clinical trials going forward. Meanwhile, the decline in new cases has investigators revamping or even canceling trials at a time when manufacturers finally have enough supplies to test some of the most promising experimental drugs. The toll of the outbreak ticked up last week, as Guinea, Liberia, and Sierra Leone—the three most affected countries—counted 124 confirmed cases, up from 99 cases the week before. As the World Health Organization’s (WHO’s) Bruce Aylward said at a press conference on 5 February: “The virus has told us this week, loud and clear, ‘I am not going to go away the way you’re expecting me to.’ ” Yet the numbers represent a sharp drop from the height of the epidemic in September when there were more than 700 cases reported in a single week in West Africa. Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)Just last week, the Wellcome Trust, a charity in the United Kingdom that is funding several Ebola trials, announced that the Liberian trial of brincidofovir, an antiviral developed by Chimerix of Durham, North Carolina, would be canceled because the company withdrew support. “It was rather a surprise to us and a bit of a mystery,” says Peter Horby, an investigator at the University of Oxford in the United Kingdom who headed the study. Chimerix said it made the decision after discussions with the U.S. Food and Drug Administration (FDA), noting that the trial was also having trouble recruiting patients. Horby says his group was planning to open a second trial site in Sierra Leone, where the numbers are far higher. FDA’s Luciana Borio says Chimerix also refused the agency’s request to make public its correspondence with the company. Chimerix said it was concentrating on completing trials of the drug to treat other infections: cytomegalovirus and adenovirus.Although one trial is canceled, others are about to go forward. Horby says his group hopes to start evaluating an RNA inhibitor called TKM-Ebola soon. The drug, made by Tekmira Pharmaceuticals of Burnaby, Canada, worked well in monkeys but has been in short supply.Testing is also about to begin on the antibody cocktail ZMapp. Seen by many researchers as the best shot at treating Ebola because of promising monkey studies, ZMapp was used on nine patients last summer before the company behind it, Mapp Biopharmaceutical of San Diego, California, announced it had no more supplies. Now, the company says, it has enough doses to start a clinical trial in Liberia as early as this week. But there may be too few patients in that country for the experimental drug to prove its worth, says Clifford Lane, head of clinical research at the U.S. National Institute of Allergy and Infectious Diseases, which is launching the study in Monrovia with the Liberian Ministry of Health & Social Welfare.So far, Guinea and Sierra Leone, where Ebola is still infecting dozens of people a week, have refused invitations to join the study. Their main stumbling block is trial design. ZMapp will be the first Ebola treatment that will be tested in a randomized, controlled study. “I think that’s the only way to tell whether these drugs are safe and effective,” Lane says.The governments of Guinea and Sierra Leone, as well as Doctors Without Borders, which runs Ebola centers in those countries, have for ethical reasons been reluctant to participate in treatment trials that use a randomized, controlled design. Jeremy Farrar, head of the Wellcome Trust, also objects to the randomized, controlled trial design for Ebola drugs, given the high mortality rate of the disease. “Given the data we have from animals and individual patients, I would not feel comfortable being randomized,” he says. Lane notes that the trial may not need many participants: If the drug is 100% effective and Ebola kills 50% of the people it infects, he says, as few as 30 people will need to receive ZMapp to determine whether it works. And even if there are not enough patients to provide a clear answer on efficacy, Lane says scientists might still get valuable data by looking at parameters like the blood levels of Ebola virus in those treated with the drug and those in the control arm.The favipiravir study in Guinea illustrates the complexity of discerning clear answers without a robust control and the difficulties of communicating them. The trial data are reviewed every 20 patients by an independent monitoring board. On 26 January they evaluated the data from 80 patients. Because they detected a signal of efficacy, they asked the researchers to share the information with regulatory agencies in Guinea and France, Levy says. The INSERM researchers won’t make their data public until 25 February, at the Conference on Retroviruses and Opportunistic Infections in Seattle, Washington. “It is important to have a scientific debate about what these results really mean,” says Levy, noting that the meeting organizers insisted the data be embargoed. A researcher who had seen the data and asked not to be identified told Science that favipiravir did not help all of the patients treated with it at two trial sites in Guinea. In a subset of trial participants who had low levels of Ebola virus in the blood, however, the mortality was just 15%. In similar patients who entered the centers earlier and did not receive favipiravir, mortality was 30%. Marie-Paule Kieny, an assistant director-general at WHO, says it is difficult to make sense of the data at this point. “You can say it doesn’t mean anything or you can say it is promising. More research is needed to find out what really happened.”Meanwhile, the study in Guinea is continuing and has now enrolled more than 100 patients. “The final result may still be different,” Levy says. But the preliminary data have already led Guinean authorities to expand the numbers of sites where favipiravir is to be used.Other trials could prove harder to organize and interpret if favipiravir is distributed widely. A study testing the use of convalescent serum started in Guinea this week. “If there is a decision now to use favipiravir everywhere, what happens with that trial?” Kieny asks. The ZMapp trial may also be affected. That trial is designed to compare ZMapp with the standard of care. “If the standard of care changes, so does the control used in the trial,” Lane says. But he has not seen any results, he says. “The only data I have seen from that study are what was in The New York Times.”*The Ebola Files: Given the current Ebola outbreak, unprecedented in terms of number of people killed and rapid geographic spread, Science and Science Translational Medicinehave made a collection of research and news articles on the viral disease freely available to researchers and the general public.*Correction, 13 February, 11:05 a.m.: This story incorrectly referred to a trial of ZMapp, an Ebola antibody cocktail, as being a placebo-controlled trial. As the story reports, ZMapp will be tested in a trial that, for the first time, uses a randomized, control group. But the control group will not receive a placebo. People in the control arm will receive the current standard of care, which includes providing intravenous fluids, balancing electrolytes, maintaining oxygen status and blood pressure, and treating other infections if they occur.
FILE – At left, in a Jan. 28, 2019, file photo, Duke’s RJ Barrett (5) dunks against Notre Dame during the second half of an NCAA college basketball game, in South Bend, Ind. At right, in a Jan. 19, 2019, file photo, Duke’s Zion Williamson (1) drives to the basket against Virginia during the second half of an NCAA college basketball game, in Durham, N.C. Duke freshmen RJ Barrett and Zion Williamson are 1-2 in the league in scoring. They could end up that way for top ACC player, too. (AP Photo/File) LOS ANGELES — Duke teammates Zion Williamson and RJ Barrett, along with Gonzaga’s Brandon Clarke and Rui Hachimura, are among 15 players on the ballot for the John R. Wooden Award that goes to the nation’s outstanding college basketball player.The other contenders are Jarrett Culver of Texas Tech, Mike Daum of South Dakota State, Carsen Edwards of Purdue, Ethan Happ of Wisconsin, Markus Howard of Marquette, De’Andre Hunter of Virginia, Dedric Lawson of Kansas, Ja Morant of Murray State, PJ Washington of Kentucky, Grant Williams of Tennessee and Cassius Winston of Michigan State.ADVERTISEMENT Lakers’ Brandon Ingram out for season with deep venous thrombosis SEA Games hosting troubles anger Duterte P2.5 B shabu seized in Makati sting, Chinese national nabbed Sports Related Videospowered by AdSparcRead Next Trump campaign, GOP groups attack Google’s new ad policy Lacson backs proposal to elect president and vice president in tandem For the complete collegiate sports coverage including scores, schedules and stories, visit Inquirer Varsity. The ballot was announced Saturday by the Los Angeles Athletic Club.Voting by a national media panel takes place March 18-25, which includes the opening rounds of the NCAA Tournament. Fans can vote online.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSUrgent reply from Philippine football chiefSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesThe top 10 vote-getters will be named to the Wooden Award All American team after the Elite Eight round of the NCAA Tournament. Five finalists will vie for the Wooden Award to be presented on April 12 in Los Angeles. 1 dead, 3 injured in Quezon road crash Hong Kong tunnel reopens, campus siege nears end Private companies step in to help SEA Games hosting P2.5 B shabu seized in Makati sting, Chinese national nabbed Don’t miss out on the latest news and information. LATEST STORIES MOST READ PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss View comments